Protein Structure Lab Services
The Protein Structure Laboratory offers a range of services in the area of protein structure determination.
Services Offered:
- Protein construct design, expression and purification for crystallization (gene-to-structure)
- Protein crystallization (only 12 mL of protein needed per 96-well screen)
- High throughput methods using robotics for crystallization and crystal imaging
- Screening of protein ligand, inhibitor complexes and protein:protein complexes
- Membrane protein crystallization
- X-ray diffraction testing and data collection
- Synchrotron data collection (~300 synchrotron data sets collected annually)
- Structure solution and refinement using modern crystallographic software
- ~50 structures determined annually
- Structure of protein:inhibitor complexes to support drug development
- Training of students in all aspects of protein crystallography
- Computational laboratory with Linux workstations
- Preparation of publication ready structure reports
- Preparation of grant materials for collaborative research proposals
